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2021

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Medical Physics

Peer-reviewed journals:

  1. F.S.Englbrecht, S.Trinkl, V.Mares, W.Rühm, M.Wielunski, J.J.Wilkens, M.Hillbrand, K.Parodi: A comprehensive Monte Carlo study of out-of-field secondary neutron spectra in a scanned-beam proton therapy gantry room, Zeitschrift für Medizinische Physik, available online 20 February 2021, https://doi.org/10.1016/j.zemedi.2021.01.001
  2. J. Lascaud, P. Dash, M. Würl, H.-P. Wieser, B. Wollant, R. Kalunga, W. Assmann, D.-A. Clevert, A. Ferrari, P. Sala, A. S. Savoia and K. Parodi: Enhancement of the ionoacoustic effect through ultrasound and photoacoustic contrast agents, 2021, Scientific Reports 11, 2725.
  3. P. Palaniappan; S. Meyer; F. Kamp; C. Belka; M. Riboldi; K. Parodi, C. Gianoli. Deformable image registration of the treatment planning CT with proton radiographies in perspective of adaptive proton therapy. Phys Med Biol 66 (4), 045008
  4. K. Czerska; F. Emert; R. Kopec; K. Langen; J.R. McClelland; A. Meijers; N. Miyamoto; M. Riboldi; S. Shimizu; T. Terunuma; W. Zou; A. Knopf; A. Rucinski. Clinical practice vs. state-of-the-art research and future visions: Report on the 4D treatment planning workshop for particle therapy–Edition 2018 and 2019. Phys Med 82, 54-63
  5. M. Rabe; C. Paganelli; M. Riboldi; D. Bondesson; M.J. Schneider; T. Chmielewski; G. Baroni; J. Dinkel; M. Reiner; G. Landry; K. Parodi; C. Belka; F. Kamp; C. Kurz. Porcine lung phantom-based validation of estimated 4D-MRI using orthogonal cine imaging for low-field MR-Linacs. Phys Med Biol 16;66(5):055006.
  6. M. Rädler; C. Gianoli; P. Palaniappan; K. Parodi; M. Riboldi. Electromagnetic Signal of a Proton Beam in Biological Tissues for a Potential Range-Verification Approach in Proton Therapy. Physical Review Applied 15 (2), 024066
  7. E. Lombardo; C. Kurz; S. Marschner; M. Avanzo; V. Gagliardi; G. Fanetti; G. Franchin; J. Stancanello; S. Corradini; M. Niyazi; C. Belka; K. Parodi; M. Riboldi; G. Landry. Distant metastatisis time to event analysis with CNNs in independent head and neck cancer cohorts. Scientific Reports, 11, 6418
  8. G. Meschini; C Paganelli; A Vai; G Fontana; S Molinelli; A Pella; V Vitolo; A Barcellini; E Orlandi; M Ciocca; M Riboldi; G Baroni. An MRI framework for respiratory motion modelling validation. J Med Imaging Radiat Oncol. 65 (3), 337-344.
  9. J. Lascaud, P. Dash, H.-P., Wieser, R. Kalunga, M. Würl, W. Assmann and K. Parodi: Investigating the accuracy of co-registered ionoacoustic and ultrasound images in pulsed proton beams, 2021, Physics in Medicine & Biology 66, 185007.
  10. T. Binder, H.G. Kang, M. Nitta, F. Schneider, T. Yamaya, K. Parodi, F. Wiest and P.G. Thirolf, Performance evaluation of a staggered 3-layer DOI PET detector using a 1 mm LYSO pitch with PETsys TOFPET2 ASIC: Comparison of Hamamatsu and KETEK SiPMs, Phys. Med. Biol. 66, 125016 (2021), https://iopscience.iop.org/article/10.1088/1361-6560/abfbf3
  11. M. Kawula, T.M. Binder, S. Liprandi, R. Viegas, K. Parodi, P.G. Thirolf, Sub-millimeter precise photon interaction position determination in large
    monolithic scintillators via convolutional neural network algorithms, Phys. Med. Biol. 66, 135017 (2021), https://iopscience.iop.org/article/10.1088/1361-6560/ac06e2/pdf
  12. D. Boscolo, D. Kostyleva, M.J. Safari, V. Anagnostatou, J. Aysto, S. Bagchi, T. Binder, G. Dedes, P. Dendooven, T. Dickel, V. Drozd, B. Franczack, H. Geissel, C. Gianoli, C. Graeff, T. Grahn, F. Greiner, E. Haettner, R. Haghani, M.N. Harakeh, F. Horst, C. Hornung, J.-P. Hucka, N. Kalantar-Nayestanaki, E. Kazantseva, B. Kindler, R. Kn\"obel, N. Kuzminchuk-Feuerstein, B. Lommel, I. Mukha, C. Nociforo, S. Ishikawa, G. Lovatti, M. Nitta, I. Ozoemelam, S. Pietri, W.R. Plaß, A. Prochazka, S. Purushothaman, C.-A. Reidel, H. Roesch, F. Schirru, C. Schuy, O. Sokol, T. Steinsberger, Y.K. Tanaka, I. Tanihata, P.G. Thirolf, W. Tinganelli, B. Voss, U. Weber, H. Weick, J.S. Winfield, M. Winkler, J. Zhao, C. Scheidenberger, K. Parodi, M. Durante, Radioactive beams for image-guided particle therapy: the BARB experiment at GSI, Frontiers in Oncology 11, 737050 (2021); https://doi.org/10.3389/fonc.2021.73705
  13. S.N. Marschner, E. Lombardo, L. Minibek, A. Holzgreve, L. Kaiser, N.L. Albert, C. Kurz, M. Riboldi, R. Späth, P. Baumeister, M. Niyazi, C. Belka, S. Corradini, G. Landry, F. Walter. Risk Stratification Using 18F-FDG PET/CT and Artificial Neural Networks in Head and Neck Cancer Patients Undergoing Radiotherapy, Diagnostics 11 (9), 1581
  14. Dickmann J, Sarosiek C, Götz S, Pankuch M, Coutrakon G, Johnson RP, Schulte RW, Parodi K, Landry G, Dedes G: An empirical artifact correction for proton computed tomography. Phys Med. 2021 Jun;86:57-65
  15. Hofmaier J, Dedes G, Carlson DJ, Parodi K, Belka C, Kamp F: Variance-based sensitivity analysis for uncertainties in proton therapy: A framework to assess the effect of simultaneous uncertainties in range, positioning, and RBE model predictions on RBE-weighted dose distributions. Med Phys. 2021 Feb;48(2):805-818
  16. Tian L, Huang Z, Janssens G, Landry L, Dedes G, Kamp F, Belka C, Pinto M, Parodi K: Accounting for prompt gamma emission and detection for range verification in proton therapy treatment planning. Phys Med Biol. 2021 Feb 16;66(5):055005
  17. Dickmann J, Sarosiek C, Rykalin V, Pankuch M, Coutrakon G, Johnson RP, Bashkirov V, Schulte RW, Parodi K, Landry G, Dedes G: Proof of concept image artifact reduction by energy-modulated proton computed tomography (EMpCT). Phys Med. 2021 Jan;81:237-244
  18. Dickmann J, Kamp F, Hillbrand M, Corradini S, Belka C, Schulte RW, Parodi K, Dedes G, Landry G: Fluence-modulated proton CT optimized with patient-specific dose and variance objectives for proton dose calculation. Phys Med Biol. 2021 Mar 2;66(6):064001
  19. Hofmaier J, Walter F, Hadi I, Rottler M, von Bestenbostel R, Dedes G, Parodi K, Niyazi M, Belka C, Kamp F: Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy. Phys Imaging Radiat Oncol. 2021 Dec 2;20:117-120
  20. Wieser HP, Huang Y, Schauer J, Lascaud J, Würl M, Lehrack S, Radonic D, Vidal M, Hérault J, Chmyrov A, Ntziachristos V, Assmann W, Parodi K, Dollinger G.: Experimental demonstration of accurate Bragg peak localization with ionoacoustic tandem phase detection (iTPD). Phys Med Biol. 2021 Dec 16; 66(24). doi: 10.1088/1361-6560/ac3ead. PMID: 34847532

  21. Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI.
    Boscolo D, Kostyleva D, Safari MJ, Anagnostatou V, Äystö J, Bagchi S, Binder T, Dedes G, Dendooven P, Dickel T, Drozd V, Franczack B, Geissel H, Gianoli C, Graeff C, Grahn T, Greiner F, Haettner E, Haghani R, Harakeh MN, Horst F, Hornung C, Hucka JP, Kalantar-Nayestanaki N, Kazantseva E, Kindler B, Knöbel R, Kuzminchuk-Feuerstein N, Lommel B, Mukha I, Nociforo C, Ishikawa S, Lovatti G, Nitta M, Ozoemelam I, Pietri S, Plaß WR, Prochazka A, Purushothaman S, Reidel CA, Roesch H, Schirru F, Schuy C, Sokol O, Steinsberger T, Tanaka YK, Tanihata I, Thirolf P, Tinganelli W, Voss B, Weber U, Weick H, Winfield JS, Winkler M, Zhao J, Scheidenberger C, Parodi K, Durante M; Super-FRS Experiment Collaboration. Front Oncol. 2021 Aug 19;11:737050. doi: 10.3389/fonc.2021.737050. eCollection 2021. PMID: 34504803 Free PMC article.
    12
    Investigating the accuracy of co-registered ionoacoustic and ultrasound images in pulsed proton beams.
    Lascaud J, Dash P, Wieser HP, Kalunga R, Würl M, Assmann W, Parodi K. Phys Med Biol. 2021 Sep 9;66(18). doi: 10.1088/1361-6560/ac215e. PMID: 34438378
    13
    Validation of proton dose calculation on scatter corrected 4D cone beam computed tomography using a porcine lung phantom.
    Schmitz H, Rabe M, Janssens G, Bondesson D, Rit S, Parodi K, Belka C, Dinkel J, Kurz C, Kamp F, Landry G. Phys Med Biol. 2021 Aug 30;66(17). doi: 10.1088/1361-6560/ac16e9. PMID: 34293737
    14
    Proton range uncertainty reduction benefits for skull base tumors in terms of normal tissue complication probability (NTCP) and healthy tissue doses.
    Tattenberg S, Madden TM, Gorissen BL, Bortfeld T, Parodi K, Verburg J. Med Phys. 2021 Sep;48(9):5356-5366. doi: 10.1002/mp.15097. Epub 2021 Jul 29. PMID: 34260085
    15
    Time trends and disparities in anxiety among adolescents, 2012-2018.
    Parodi KB, Holt MK, Green JG, Porche MV, Koenig B, Xuan Z. Soc Psychiatry Psychiatr Epidemiol. 2022 Jan;57(1):127-137. doi: 10.1007/s00127-021-02122-9. Epub 2021 Jun 7. PMID: 34100110 Free PMC article.
    16
    Sub-millimeter precise photon interaction position determination in large monolithic scintillators via convolutional neural network algorithms.
    Kawula M, Binder TM, Liprandi S, Viegas R, Parodi K, Thirolf PG. Phys Med Biol. 2021 Jul 2;66(13). doi: 10.1088/1361-6560/ac06e2. PMID: 34062523
    We thereby improved the performance by more than a factor of 2.5 compared to the previously used categorical average pattern algorithm, which is a variation of the well-established k-nearest neighbor algorithm. The trained CNN has a low memory footprint and enables the rec …
    17
    An empirical artifact correction for proton computed tomography.
    Dickmann J, Sarosiek C, Götz S, Pankuch M, Coutrakon G, Johnson RP, Schulte RW, Parodi K, Landry G, Dedes G. Phys Med. 2021 Jun;86:57-65. doi: 10.1016/j.ejmp.2021.05.018. Epub 2021 May 28. PMID: 34058718
    18
    Corrigendum: Beam characterization and feasibility study for a small animal irradiation platform at clinical proton therapy facilities (2020Phys. Med. Biol.65 245045).
    Gerlach S, Pinto M, Kurichiyanil N, Grau C, Hérault J, Hillbrand M, Poulsen PR, Safai S, Schippers JM, Schwarz M, Søndergaard CS, Tommasino F, Verroi E, Vidal M, Yohannes I, Schreiber J, Parodi K. Phys Med Biol. 2021 Apr 6;66(7). doi: 10.1088/1361-6560/abf00e. PMID: 34037545 No abstract available.
    19
    Measurement-based range evaluation for quality assurance of CBCT-based dose calculations in adaptive proton therapy.
    Neppl S, Kurz C, Köpl D, Yohannes I, Schneider M, Bondesson D, Rabe M, Belka C, Dietrich O, Landry G, Parodi K, Kamp F. Med Phys. 2021 Aug;48(8):4148-4159. doi: 10.1002/mp.14995. Epub 2021 Jun 29. PMID: 34032301
    20
    Assessment of the Sun Nuclear ArcCHECK to detect errors in 6MV FFF VMAT delivery of brain SABR using ROC analysis.
    Tattenberg S, Hyde D, Milette MP, Parodi K, Araujo C, Carlone M. J Appl Clin Med Phys. 2021 Jun;22(6):35-44. doi: 10.1002/acm2.13276. Epub 2021 May 21. PMID: 34021691

Abstracts and conference proceedings

  1. Tim Binder, Vasiliki Anagnostatou, Jennifer Zhou, Kei Kamada, Katia Parodi, and Peter G. Thirolf,  A GAGG-based scatter component for Compton imaging below 1.5 MeV, Verhandl. DPG (VI), 56, ST 12.1 (2021)
  2. Jennifer Zhou, Tim Binder, Kei Kamada, Katia Parodi und Peter G. Thirolf, Untersuchungen der ortsaufgelösten Energieauflösung der Einzelkomponenten eines Compton-Kamera-Prototypen, Verhandl. DPG (VI), 56, ST 12.2 (2021)
  3. Tim Binder, Vasiliki Anagnostatou, Kei Kamada, Han Gyu Kang, Munetaka Nitta, Mohammad Safari, Katia Parodi, Taiga Yamaya, Peter G. Thirolf, Towards a γ-PET prototype – commissioning and first images in compton and PET mode, DGMP Dreiländertagung 2021 (online), V31
  4. Munetaka Nitta, Giulio Lovatti, Han Gyu Kang, Roghieh Haghani, Tim Binder, Mohammad Safari, George Dedes, Peter G. Thirolf, Taiga Yamaya, Katia Parodi,  Finalisation and performance evaluation of a novel PET detector for an in-beam small animal PET scanner, DGMP Dreiländertagung 2021 (online), V23
  5. E Lombardo, C Kurz, S Marschner, M Avanzo, V Gagliardi, G Fanetti, G Franchin, J Stancanello, S Corradini, M Niyazi, C Belka, K Parodi, M Riboldi, G Landry. OC-0526 Deep learning based time-to-event prediction for a large multicentric cohort of H&N cancer patients. Radiotherapy and Oncology 161, S412-S413
  6. M Rabe, C Paganelli, H Schmitz, G Meschini, M Riboldi, J Hofmaier, J Dinkel, M Reiner, K Parodi, C Belka, G Landry, C Kurz, F Kamp. Time-Resolved Estimated Synthetic CTs Based on Orthogonal Cine MRI for Low-Field MR-Linac Treatments. Medical Physics 48 (6)
  7. K Traeuble, P Palaniappan, C Gianoli, C Paganelli, G Baroni, F Kamp, C Belka, C Kurz, G Landry, M Riboldi. Optimization of the imaging Plane for Real-Time Tumor Tracking in MR-Guided Radiotherapy of Moving Targets. Medical Physics 48 (6)
  8. E Lombardo, L Minibek, A Holzgreve, L Kaiser, N Albert, P Bartenstein, C Kurz, M Riboldi, M Niyazi, C Belka, S Corradini, F Walter, G Landry, S Marschner. Risk Stratification with the Aid of 18F-FDG-PET/CT and neural Networks in Head and Neck Cancer Patients. Strahlentherapie und Onkologie, 197 (SUPPL 1),S62

Laser-Ion-Acceleration

Peer-reviewed journals:

Abstracts and conference proceedings:

Nuclear Physics

Peer-reviewed journals:

  1. I. Alencar, M. Hatori, G.G. Marmitt, H. Trombini, P.L. Grande, J.F. Dias, R.M. Papaléo, A. Mücklich, W. Assmann, M. Toulemonde, C. Trautmann: Nanoparticle emission by electronic sputtering of CaF2 single crystals, Appl. Surf. Sci. 537 (2021) 147821, https://doi.org/10.1016/j.apsusc.2020.147821
  2. E. Peik, T. Schumm, M.S. Safronova, A. Palffy, J. Weitenberg and P.G. Thirolf, Nuclear clocks for testing fundamental physics, Quantum Sci. Technol. 6, 034002 (2021), https://iopscience.iop.org/article/10.1088/2058-9565/abe9c2
  3. P.G. Thirolf, B. Seiferle, L. v.d. Wense, The Thorium Isomer - Heartbeat for a Nuclear Clock, Nuclear Physics News 31, 13-18 (2021), https://doi.org/10.1080/10619127.2020.1832809

Abstracts and conference proceedings:

  1. Oliver Kaleja, Brankica Andelic, Luisa Arcila Gonzalez, Joacquín Berrocal, Lennart Blaauw, Klaus Blaum, Michael Block, Pierre Chauveau, Stanislav Chenmarev, Premaditya Chhetri, Christoph E. Düllmann, Martin Eibach, Julia Even, Pavel Filianin, Francesca Giacoppo, Manuel J. Gutiérrez Torres, Fritz P. Hessberger, Nasser Kalantar-Nayestanaki, Jacques J. W. van de Laar, Mustapha Laatiaoui, Steffen Lohse, Enrique Minaya Ramirez, Andrew Mistry, Elodie Morin, Yury Nechiporenko, Dennis Neidherr, Steven Nothhelfer, Yuri Novikov, Sebastian Raeder, Elisabeth Rickert, Daniel Rodríguez, Lutz Schweikhard, Peter G. Thirolf, Jessica Warbinek, and Alexander Yakushev, High-Precision Mass Spectrometry of Superheavy Elements, Verhandl. DPG (VI), 56, MS 2.3 (2021)
  2. Francesca Giacoppo, Brankica Anďelić, Luisa Arcila Gonzalez, Joaquín Berrocal Sánchez, Lennart Blaauw, Klaus Blaum, Michael Block, Pierre Chauveau, Stanislav Chenmarev, Premaditya Chhetri, Christoph E. Düllmann, Martin Eibach, Julia Even, Pavel Filianin, Manuel Jesús Gutiérrez Torres, Fritz P. Heßberger, Nasser Kalantar-Nayestanaki, Oliver Kaleja, Jacques W. van de Laar, Mustapha Laatiaoui, Steffen Lohse, Enrique Minaya Ramirez, Andrew Mistry, Elodie Morin, Yury Nechiporenko, Dennis Neidherr, Steven Nothhelfer, Yuri Novikov, Sebastian Raeder, Elisabeth Rickert, Daniel Rodríguez, Lutz Schweikhard, Peter Thirolf, Jessica Warbinek, and Alexander Yakushev, Investigation of ground and metastable nuclear states in the heaviest nuclei at SHIPTRAP, Verhandl. DPG (VI), 56, MS 2.4 (2021)
  3. Peter G Thirolf, B. Seiferle, L. v.d. Wense, I. Amersdorffer, K. Scharl, D. Moritz, S. Ding, F. Zacherl, J. Thielking, P. Glowacki, D.M. Meier, M. Okhapkin, E. Peik, C. Mokry, J. Runke, K. Eberhardt, N.G. Trautmann, C.E. Düllmann, Demystifying the 229-Thorium Isomer: Towards the Nuclear Clock, 52nd Annual Meeting of the APS Division of Atomic, Molecular and Optical Physics, Bulletin of the American Physical Society Vol. 66, Number 6 (2021), Abstract: Q02.00004

Detector Development and High Energy Physics

  1. S. Aune, J. Bortfeldt, F. Brunbauer, C. David, D. Desforge, G. Fanourakis, M. Gallinaro, F. García, I. Giomataris, T. Gustavsson, F.J. Iguaz, M. Kebbiri, K. Kordas, C. Lampoudis, P. Legou, M. Lisowska, J. Liu, M. Lupberger, O. Maillard, I. Maniatis, I. Manthos, H. Müller, E. Oliveri, T. Papaevangelou, K. Paraschou, M. Pomorski, B. Qi, F. Resnati, L. Ropelewski, D. Sampsonidis, L. Scharenberg, T. Schneider, L. Sohl, M. van Stenis, A. Tsiamis, Y. Tsipolitis, S.E. Tzamarias, A. Utrobicic, R. Veenhof, X. Wang, S. White, Z. Zhang, Y. Zhou; Timing performance of a multi-pad PICOSEC-Micromegas detector prototype; Nucl. Instrum. and Meth. A993 (2021), 165076,
    https://doi.org/10.1016/j.nima.2021.165076
  2. J. Bortfeldt, F. Brunbauer, C. David, D. Desforge, G. Fanourakis, M. Gallinaro, F. García, I. Giomataris, T. Gustavsson, F.J. Iguaz, M. Kebbiri, K. Kordas, C. Lampoudis, P. Legou, M. Lisowska, J. Liu, M. Lupberger, O. Maillard, I. Manthos, H. Müller, V. Niaouris, E. Oliveri, T. Papaevangelou, K. Paraschou, M. Pomorski, B. Qi, F. Resnati, L. Ropelewski, D. Sampsonidis, L. Scharenberg, T. Schneider, L. Sohl, M. van Stenis, Y. Tsipolitis, S.E. Tzamarias, A. Utrobicic, R. Veenhof, X. Wang, S. White, Z. Zhang, Y. Zhou; Modeling the timing characteristics of the PICOSEC Micromegas detector; Nucl. Instrum. and Meth. A993 (2021) 165049, https://doi.org/10.1016/j.nima.2021.165049

Books and Book Chapters

Books

Bookchapter

Thesis Works

PhD:

Master Thesis (internal):

G. Liubchenko: A Feasibility Study of High-Z Metal (Oxide) Nanoparticles as Contrast Agents for Proton Imaging at a Small Animal Irradiation Platform

D. Radonic: Measuring the Ionoacoustic Time of Flight in Clinical Relevant Geometries using Lock-In Detection

X. Yuqing: Analysis of Intra-fractional Prostate Motion and Its Dosimetric Impact During MR-Guided Online Adaptive Radiotherapy

M. Stanislawski: PET Activation Studies and 3D Gel Dosimetry for Proton Range Verification

S. Götz: Evaluation of Image Quality and Dose Efficiency in Proton and Helium Computed Tomography with Monte Carlo Simulation

L. Zott: A Computational Framework to Validate a Prototype Planning System for a Small Animal Proton Irradiatior

Bachelor Thesis (internal):

D. Lovric: Optimisation of Construction Processes for Large, Ultra Thin Micromegas Detectors

O. Schackmann: Development of a Time Projection Chamber and its Micromegas Readout Structure for the SIRMIO Project

J. Kainhuber: Accuracy and Precision of Time-of-Flight Measurements Using a Lock-In Amplifier

A. Lange: Characterisation of an Aluminium Floating Strip Micromegas Detector

M. Estrella: Reconstruction Techniques for Accelerated MR Imaging in MR-Guided Radiotherapy

N. Homburg: Experimental Determination of the Greuneisen Parameter of Muman Tissue Surrogates via Photoacoustic Measurements

M. Meurer: Assembly and Characterisation of Thin Aluminium Floating Strip Micromegas

F. Kähler: Assembly and Initial Setup of a Time Projection Chamber (TPC) as a Range Detector of the SIRMIO Project

E. Kong Liang: Optimization of the Backing material of Low Frequency PVDF Sensors for Ionoacoustic-Based Range Verification During Small Animal Proton Radiation

P. Oberländer: Evaluation of the Intrinsic Spatial Resolution of a Scintillator and Silicon Photomultiplier Gamma Ray Detector Unit for Positron Emission Tomography

D. Selzner: Development Towards a Variable Calibration Water Phantom for a Small-Animal Proton Imaging Setup

S. Schwaiger: Calibration and Commissioning of a Small-Animal Proton Imaging Setup Based On Timepix3 Detectors

Master Thesis (external)

G. Vradhzeva: Dosimetric Measurements at the SARRP for Validation of New TPS (Abteilung für Radioonkologie LMU Klinikum)

B. Kotulski: Validation of deep learning-based glioma segmentation usen (18F)FET PET Data and comparison with established PET segmentation methods (LMU, Klinik für Neklearmedizin)

 Bachelor Thesis (external):

Zulassungsarbeit (State exam thesis):