Experimental Medical Physics

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Medical Physics

Peer-reviewed journals:

  1. Assmann, W., Becker, R., Stief, C. and Sroka, R. (2022). Development and pre-clinical test of a phosphorous-32 containing polyetheretherketone foil aiming at urethral stricture prevention by low-dose-rate brachytherapy. Journal of Contemporary Brachytherapy, 14(2), 189-197. https//doi.org/10.5114/jcb.2022.115205
  2. Bauer, J., Hildebrandt, M., Baumgartl, M., Fiedler, F., Robert, C., Buvat, I., Enghardt, W. and Parodi, K. (2022). Quantitative assessment of radionuclide production yields in in-beam and offline PET measurements at different proton irradiation facilities. Physics in Medicine & Biology, 67(15), 155001. https//doi.org/10.1088/1361-6560/ac7a89
  3. Binder, T.M., Anagnostatou, V., Dedes, G., Kamada, K., Kang, H.G., Lovatti, G., Nitta, M., Safari, M., Zoglauer, A., Parodi, K., Yamaya, T. and Thirolf, P. (2022). Component characterization and commissioning of a gamma-PET prototype detector system. Frontiers in Physics, 10, 954204. https//doi.org/10.3389/fphy.2022.954204
  4. Bondesson, D., Meijers, A., Janssens, G., Rit, S., Rabe, M., Kamp, F., Niepel, K., Otter, L.A.D., Both, S., Brousmiche, S., Dinkel, J., Belka, C., Parodi, K., Knopf, A., Kurz, C. and Landry, G. (2022). Anthropomorphic lung phantom based validation of in-room proton therapy 4D-CBCT image correction for dose calculation. Zeitschrift für Medizinische Physik, 32(1), 74-84. https//doi.org/10.1016/j.zemedi.2020.09.004
  5. Boscolo, D., Kostyleva, D., Schuy, C., Weber, U., Haettner, E., Purushothaman, S., Dendooven, P., Dickel, T., Drozd, V., Franczack, B., Geissel, H., Hornung, C., Horst, F., Kazantseva, E., Kuzminchuk-Feuerstein, N., Lovatti, G., Mukha, I., Nociforo, C., Pietri, S., Pinto, M., Reidel, C.-A., Roesch, H., Sokol, O., Tanaka, Y.K., Weick, H., Zhao, J., Scheidenberger, C., Parodi, K. and Durante, M. (2022). Depth dose measurements in water for 11C and 10C beams with therapy relevant energies. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1043, 167464. https//doi.org/10.1016/j.nima.2022.167464
  6. Dedes, G., Dickmann, J., Giacometti, V., Rit, S., Krah, N., Meyer, S., Bashkirov, V., Schulte, R., Johnson, R.P., Parodi, K. and Landry, G. (2022). The role of Monte Carlo simulation in understanding the performance of proton computed tomography. Zeitschrift für Medizinische Physik, 32(1), 23-38. https//doi.org/10.1016/j.zemedi.2020.06.006
  7. Dedes, G., Drosten, H., Götz, S., Dickmann, J., Sarosiek, C., Pankuch, M., Krah, N., Rit, S., Bashkirov, V., Schulte, R.W., Johnson, R.P., Parodi, K., DeJongh, E. and Landry, G. (2022). Comparative accuracy and resolution assessment of two prototype proton computed tomography scanners. Medical Physics, 49(7), 4671-4681. https//doi.org/10.1002/mp.15657
  8. Dumlu, H.S., Meschini, G., Kurz, C., Kamp, F., Baroni, G., Belka, C., Paganelli, C. and Riboldi, M. (2022). Dosimetric impact of geometric distortions in an MRI-only proton therapy workflow for lung, liver and pancreas. Zeitschrift für Medizinische Physik, 32(1), 85-97. https//doi.org/10.1016/j.zemedi.2020.10.002
  9. Eder, M.M., Reiner, M., Heinz, C., Garny, S., Freislederer, P., Landry, G., Niyazi, M., Belka, C. and Riboldi, M. (2022). Single-isocenter stereotactic radiosurgery for multiple brain metastases: Impact of patient misalignments on target coverage in non-coplanar treatments. Zeitschrift für Medizinische Physik, 32(3), 296-311. https//doi.org/10.1016/j.zemedi.2022.02.005
  10. El Naqa, I., Pogue, B.W., Zhang, R., Oraiqat, I. and Parodi, K. (2022). Image guidance for FLASH radiotherapy. Medical Physics, 49(6), 4109-4122. https//doi.org/10.1002/mp.15662
  11. Farr, J.B., Parodi, K. and Carlson, D.J. (2022). FLASH: Current status and the transition to clinical use. Medical Physics, 49(3), 1972-1973. https//doi.org/10.1002/mp.15401
  12. Götz, S., Dickmann, J., Rit, S., Krah, N., Khellaf, F., Schulte, R.W., Parodi, K., Dedes, G. and Landry, G. (2022). Evaluation of the impact of a scanner prototype on proton CT and helium CT image quality and dose efficiency with Monte Carlo simulation. Physics in Medicine & Biology, 67(5), 055003. https//doi.org/10.1088/1361-6560/ac4fa4
  13. Hu, G., Niepel, K., Risch, F., Kurz, C., Würl, M., Kröncke, T., Schwarz, F., Parodi, K. and Landry, G. (2022). Assessment of quantitative information for radiation therapy at a first-generation clinical photon-counting computed tomography scanner. Frontiers in Oncology, 12, 970299. https//doi.org/10.3389/fonc.2022.970299
  14. Kawula, M., Purice, D., Li, M., Vivar, G., Ahmadi, S.-A., Parodi, K., Belka, C., Landry, G. and Kurz, C. (2022). Dosimetric impact of deep learning-based CT auto-segmentation on radiation therapy treatment planning for prostate cancer. Radiation Oncology, 17(1), 21. https//doi.org/10.1186/s13014-022-01985-9
  15. Kollitz, E., Han, H., Kim, C.H., Pinto, M., Schwarz, M., Riboldi, M., Kamp, F., Belka, C., Newhauser, W., Dedes, G. and Parodi, K. (2022). A patient-specific hybrid phantom for calculating radiation dose and equivalent dose to the whole body. Physics in Medicine & Biology, 67(3), 035005. https//doi.org/10.1088/1361-6560/ac4738
  16. Kollitz, E., Roew, M., Han, H., Pinto, M., Kamp, F., Kim, C.H., Schwarz, M., Belka, C., Newhauser, W., Parodi, K. and Dedes, G. (2022). Applications of a patient-specific whole-body CT-mesh hybrid computational phantom in second cancer risk prediction. Physics in Medicine & Biology, 67(18), 185011. https//doi.org/10.1088/1361-6560/ac8851
  17. Lascaud, J., Dash, P., Schnürle, K., Bortfeldt, J., Niepel, K., Maas, J., Würl, M., Vidal, M., Hérault, J., Landry, G., Savoia, A.S., Lauber, K. and Parodi, K. (2022). Fabrication and characterization of a multimodal 3D printed mouse phantom for ionoacoustic quality assurance in image-guided pre-clinical proton radiation research. Physics in Medicine & Biology, 67(20), 205001. https//doi.org/10.1088/1361-6560/ac9031
  18. Lombardo, E., Hess, J., Kurz, C., Riboldi, M., Marschner, S., Baumeister, P., Lauber, K., Pflugradt, U., Walch, A., Canis, M., Klauschen, F., Zitzelsberger, H., Belka, C., Landry, G. and Unger, K. (2022). DeepClassPathway: Molecular pathway aware classification using explainable deep learning. European Journal of Cancer, 176, 41-49. https//doi.org/10.1016/j.ejca.2022.08.033
  19. Lombardo, E., Rabe, M., Xiong, Y., Nierer, L., Cusumano, D., Placidi, L., Boldrini, L., Corradini, S., Niyazi, M., Belka, C., Riboldi, M., Kurz, C. and Landry, G. (2022). Offline and online LSTM networks for respiratory motion prediction in MR-guided radiotherapy. Physics in Medicine & Biology, 67(9), 095006. https//doi.org/10.1088/1361-6560/ac60b7
  20. Mairani, A., Mein, S., Blakely, E., Debus, J., Durante, M., Ferrari, A., Fuchs, H., Georg, D., Grosshans, D.R., Guan, F., Haberer, T., Harrabi, S., Horst, F., Inaniwa, T., Karger, C.P., Mohan, R., Paganetti, H., Parodi, K., Sala, P., Schuy, C., Tessonnier, T., Titt, U. and Weber, U. (2022). Roadmap: helium ion therapy. Physics in Medicine & Biology, 67(15), 15TR02. https//doi.org/10.1088/1361-6560/ac65d3
  21. Mohammadi, A., Tashima, H., Takyu, S., Iwao, Y., Akamatsu, G., Kang, H.G., Obata, F., Nishikido, F., Parodi, K. and Yamaya, T. (2022). Feasibility of triple gamma ray imaging of ^10 C for range verification in ion therapy. Physics in Medicine & Biology, 67(16), 165001. https//doi.org/10.1088/1361-6560/ac826a
  22. Nierer, L., Kamp, F., Reiner, M., Corradini, S., Rabe, M., Dietrich, O., Parodi, K., Belka, C., Kurz, C. and Landry, G. (2022). Evaluation of an anthropomorphic ion chamber and 3D gel dosimetry head phantom at a 0.35 T MR-linac using separate 1.5 T MR-scanners for gel readout. Zeitschrift für Medizinische Physik, 32(3), 312-325. https//doi.org/10.1016/j.zemedi.2022.01.006
  23. Palaniappan, P., Meyer, S., Rädler, M., Kamp, F., Belka, C., Riboldi, M., Parodi, K. and Gianoli, C. (2022). X-ray CT adaptation based on a 2Dtextendash3D deformable image registration framework using simulated in-room proton radiographies. Physics in Medicine & Biology, 67(4), 045003. https//doi.org/10.1088/1361-6560/ac4ed9
  24. Penescu, L., Stora, T., Stegemann, S., Pitters, J., Fiorina, E., Augusto, R.D.S., Schmitzer, C., Wenander, F., Parodi, K., Ferrari, A. and Cocolios, T.E. (2022). Technical Design Report for a Carbon-11 Treatment Facility. Frontiers in Medicine, 8, 697235. https//doi.org/10.3389/fmed.2021.697235
  25. Rutherford, H., Saha Turai, R., Chacon, A., Franklin, D.R., Mohammadi, A., Tashima, H., Yamaya, T., Parodi, K., Rosenfeld, A.B., Guatelli, S. and Safavi-Naeini, M. (2022). An inception network for positron emission tomography based dose estimation in carbon ion therapy. Physics in Medicine & Biology, 67(19), 194001. https//doi.org/10.1088/1361-6560/ac88b2
  26. Schauer, J., Wieser, H.-P., Huang, Y., Ruser, H., Lascaud, J., Würl, M., Chmyrov, A., Vidal, M., Herault, J., Ntziachristos, V., Assmann, W., Parodi, K. and Dollinger, G. (2022). Proton beam range verification by means of ionoacoustic measurements at clinically relevant doses using a correlation-based evaluation. Frontiers in Oncology, 12, 925542. https//doi.org/10.3389/fonc.2022.925542
  27. Sokol, O., Cella, L., Boscolo, D., Horst, F., Oliviero, C., Pacelli, R., Palma, G., De Simoni, M., Conson, M., Caroprese, M., Weber, U., Graeff, C., Parodi, K. and Durante, M. (2022). Potential benefits of using radioactive ion beams for range margin reduction in carbon ion therapy. Scientific Reports, 12(1), 21792. https//doi.org/10.1038/s41598-022-26290-z
  28. Tattenberg, S., Madden, T.M., Bortfeld, T., Parodi, K. and Verburg, J. (2022). Range uncertainty reductions in proton therapy may lead to the feasibility of novel beam arrangements which improve organ-at-risk sparing. Medical Physics, 49(7), 4693-4704. https//doi.org/10.1002/mp.15644
  29. Tattenberg, S., Marants, R., Niepel, K., Bortfeld, T., Sudhyadhom, A., Landry, G., Parodi, K. and Verburg, J. (2022). Validation of prompt gamma-ray spectroscopy for proton range verification in tissue-mimicking and porcine samples. Physics in Medicine & Biology, 67(20), 205006. https//doi.org/10.1088/1361-6560/ac950f
  30. Valencia Lozano, I., Dedes, G., Peterson, S., Mackin, D., Zoglauer, A., Beddar, S., Avery, S., Polf, J. and Parodi, K. (2022). Comparison of reconstructed prompt gamma emissions using maximum likelihood estimation and origin ensemble algorithms for a Compton camera system tailored to proton range monitoring. Zeitschrift für Medizinische Physik, , S0939388922000605. https//doi.org/10.1016/j.zemedi.2022.04.005
  31. Von Münchow, A., Straub, K., Losert, C., Shpani, R., Hofmaier, J., Freislederer, P., Heinz, C., Thieke, C., Söhn, M., Alber, M., Floca, R., Belka, C., Parodi, K., Reiner, M. and Kamp, F. (2022). Statistical breathing curve sampling to quantify interplay effects of moving lung tumors in a 4D Monte Carlo dose calculation framework. Physica Medica, 101, 104-111. https//doi.org/10.1016/j.ejmp.2022.07.006
  32. Wang, Y., Lombardo, E., Avanzo, M., Zschaek, S., Weingärtner, J., Holzgreve, A., Albert, N.L., Marschner, S., Fanetti, G., Franchin, G., Stancanello, J., Walter, F., Corradini, S., Niyazi, M., Lang, J., Belka, C., Riboldi, M., Kurz, C. and Landry, G. (2022). Deep learning based time-to-event analysis with PET, CT and joint PET/CT for head and neck cancer prognosis. Computer Methods and Programs in Biomedicine, 222, 106948. https//doi.org/10.1016/j.cmpb.2022.106948
  33. Wiltgen, T., Fleischmann, D.F., Kaiser, L., Holzgreve, A., Corradini, S., Landry, G., Ingrisch, M., Popp, I., Grosu, A.L., Unterrainer, M., Bartenstein, P., Parodi, K., Belka, C., Albert, N., Niyazi, M. and Riboldi, M. (2022). 18F-FET PET radiomics-based survival prediction in glioblastoma patients receiving radio(chemo)therapy. Radiation Oncology, 17(1), 198. https//doi.org/10.1186/s13014-022-02164-6
  34. Würl, M., Gianoli, C., Englbrecht, F.S., Schreiber, J. and Parodi, K. (2022). A Monte Carlo feasibility study on quantitative laser-driven proton radiography. Zeitschrift für Medizinische Physik, 32(1), 109-119. https//doi.org/10.1016/j.zemedi.2020.05.005
  35. Xiong, Y., Rabe, M., Nierer, L., Kawula, M., Corradini, S., Belka, C., Riboldi, M., Landry, G. and Kurz, C. (2022). Assessment of intrafractional prostate motion and its dosimetric impact in MRI-guided online adaptive radiotherapy with gating. Strahlentherapie und Onkologie, https//doi.org/10.1007/s00066-022-02005-1

Abstracts and conference proceedings

  1. K. Unger, E. Lombardo, J. Hess, C. Kurz, M. Riboldi, S. Marschner, P. Baumeister, K. Lauber, U. Pflugradt, A. Walch, M. Canis, F. Klauschen, H. Zitzelsberger, C. Belka, G. Landry. Regression and deep learning for transcriptome-based HPV-status prediction in head and neck cancer. Radiotherapy and Oncology 170, S1622 (2022)
  2. E. Lombardo, Y. Xiong, M. Rabe, L. Nierer, D. Cusumano, L. Placidi, L. Boldrini, S. Corradini, C. Belka, M. Riboldi, C. Kurz, G. Landry. LSTM networks for real-time respiratory motion prediction for a 0.35 T MR-linac. Radiotherapy and Oncology 170, S18-S19 (2022)
  3. Y. Xiong, M. Rabe, L. Nierer, S. Corradini, C. Belka, M. Riboldi, G. Landry, C. Kurz. Reconstructing the dosimetric impact of intra-fractional prostate motion in MR-guided radiotherapy. Radiotherapy and Oncology 170, S186-S187 (2022)
  4. M Rädler, G Buizza, P Palaniappan, C Gianoli, G Baroni, C Paganelli, K Parodi, M Riboldi. Magnetic field of a proton pencil beam as range verification method: The impact of secondaries. Radiotherapy and Oncology 170, S792-S793 (2022)
  5. Y. Wang, E. Lombardo, S. Zschaek, J. Weingärtner, A. Holzgreve, N. Albert, S. Marschner, M. Avanzo, G. Fanetti, G. Franchin, J. Stancanello, F. Walter, S. Corradini, M. Niyazi, C. Belka, M. Riboldi, C. Kurz, G. Landry. Deep learning based time to event analysis with PET, CT and joint PET/CT for H&N cancer prognosis. Radiotherapy and Oncology 170, S405-S406 (2022)
  6. Henning Geesmann, Giullio Lovatti, Tim Fitzpatrick, Jennifer Zhou, Mohammad Safari, Florian Schneider, Vassia Anagnostatou, Katia Parodi, and Peter G. Thirolf, Characterization of a multi-arm Compton-camera setup, Verhandl. DPG (VI), 57, ST 2.1 (2022)


Peer-reviewed journals:

  1. Afshari, M., Morris, S., Geulig, L.D., Chitgar, Z.M., Gibbon, P., Thirolf, P.G. and Schreiber, J. (2022). The role of collisional ionization in heavy ion acceleration by high intensity laser pulses. Scientific Reports, 12(1), 18260. https//doi.org/10.1038/s41598-022-23148-2
  2. Lindner, F.H., Fitzpatrick, E.G., Haffa, D., Ponnath, L., Schmidt, A.-K., Speicher, M., Zielbauer, B., Schreiber, J. and Thirolf, P.G. (2022). Charge-state resolved laser acceleration of gold ions to beyond 7 MeV/u. Scientific Reports, 12(1), 4784. https//doi.org/10.1038/s41598-022-08556-8

Abstracts and conference proceedings:

  1. Erin G. Fitzpatrick, Laura Geulig, Maximilian Weiser, Florian H. Lindner, and Peter G. Thirolf, Towards studying collective effects in laser-driven heavy ion acceleration, Verhandl. DPG (VI), 57, K 2.14 (2022)
  2. Laura Desiree Geulig, Erin Grace Fitzpatrick, Maximilian Weiser, Florian H. Lindner, and Peter G. Thirolf, Update on the laser heavy ion acceleration at CALA, Verhandl. DPG (VI), 57, K 7.2 (2022)

Nuclear Physics

Peer-reviewed journals:

  1. Budker, D., Berengut, J.C., Flambaum, V.V., Gorchtein, M., Jin, J., Karbstein, F., Krasny, M.W., Litvinov, Y.A., Pálffy, A., Pascalutsa, V., Petrenko, A., Surzhykov, A., Thirolf, P.G., Vanderhaeghen, M., Weidenmüller, H.A. and Zelevinsky, V. (2022). Expanding Nuclear Physics Horizons with the Gamma Factory. Annalen der Physik, 534(3), 2100284. https//doi.org/10.1002/andp.202100284
  2. Csige, L., Csatlós, M., Faestermann, T., Habs, D., Hunyadi, M., Krasznahorkay, A.J., Thirolf, P.G., Tornyi, T.G. and Wirth, H.-F. (2022). Fission resonances observed in the 237 Np (d, pf) reaction and the fission barrier topology of 238 Np. The European Physical Journal A, 58(2), 14. https//doi.org/10.1140/epja/s10050-022-00668-z
  3. Kaleja, O., Andelic, B., Bezrodnova, O., Blaum, K., Block, M., Chenmarev, S., Chhetri, P., Droese, C., Duellmann, C.E., Eibach, M., Eliseev, S., Even, J., Filianin, P., Giacoppo, F., Goetz, S., Gusev, Y., Gutiérrez, M.J., Hessberger, F.P., Kalantar-Nayestanaki, N., Van De Laar, J.J.W., Laatiaoui, M., Lohse, S., Martynova, N., Minaya Ramirez, E., Mistry, A.K., Murboeck, T., Novikov, Y., Raeder, S., Rodriguez, D., Schneider, F., Schweikhard, L., Thirolf, P.G. and Yakushev, A. (2022). Direct high-precision mass spectrometry of superheavy elements with SHIPTRAP. Physical Review C, 106(5), 054325. https//doi.org/10.1103/PhysRevC.106.054325
  4. Seiferle, B., Moritz, D., Scharl, K., Ding, S., Zacherl, F., Löbell, L. and Thirolf, P.G. (2022). Extending Our Knowledge about the 229Th Nuclear Isomer. Atoms, 10(1), 24. https//doi.org/10.3390/atoms10010024

Abstracts and conference proceedings:

  1.  Kevin Scharl, Benedict Seiferle, Shiqian Ding, Daniel Moritz, Florian Zacherl, and Peter G. Thirolf, Towards the Lifetime Measurement of the 229mTh3+ Nuclear Clock Isomer, DPG (VI), 57, MS 3.2 (2022)
  2.  Francesca Giacoppo, Brankica Anďelić, Luisa Arcila Gonzalez, Joaquín Berrocal, Lennart Blaauw, Klaus Blaum, Michael Block, Pierre Chauveau, Stanislav Chenmarev, Christoph E. Düllmann, Julia Even, Manuel J. Gutiérrez, Fritz P. Heßberger, Nasser Kalantar-Nayestanaki, Oliver Kaleja, Steffen Lohse, Enrique Minaya Ramirez, Andrew Mistry, Elodie Morin, Yury Nechiporenko, Dennis Neidherr, Steven Nothhelfer, Yuri Novikov, Sebastian Raeder, Elisabeth Rickert, Daniel Rodríguez, Lutz Schweikhard, Peter G. Thirolf, Jessica Warbinek, and Alexander Yakushev, Shedding light on low-lying metastable states in the heaviest elements with SHIPTRAP at GSI, Verhandl. DPG (VI), 57, MS 3.3 (2022)
  3. Nazarena Tortorelli, Timo Dickel, Ilkka Pohjalainen, Peter G. Thirolf, Michiharu Wada, and Jianwei Zhao, Fission isomer studies with the FRS Ion Catcher, Verhandl. DPG (VI), 57, MS 3.4 (2022)
  4. Daniel Moritz, K. Scharl, B. Seiferle, F. Zacherl, T. Dickel, F. Greiner, W. Plass, L. von der Wense, T. Leopold, P. Micke, J. Crespo López-Urrutia, P.O. Schmidt, and P.G. Thirolf, A cryogenic Paul trap setup for the determination of the ionic radiative lifetime of 229mTh3+, Verhandl. DPG (VI), 57, MS 3.5 (2022)

Detector Development and High Energy Physics

Books and Book Chapters



Thesis Works


Kollitz E.: A patient-specific CT-Mesh hybrid computational phantom and its applications in out-of-field dose, equivalent dose, and secondary cancer risk estimation in proton therapy 

Schubert P.: Methods for the acquisition and analysis of volume electron microscopy data

Rösch T. : Characterization of a Permanent Magnet Quadrupoles Focus of Laser-accelerated Protons

Englbrecht F.: Investigations of radiation shielding, diagnostic methods and imaging for conventional and laser-driven radiation sources

Master Thesis (internal):

S. Schwartzkopff: Machine Learning for Event Classification in Positron Emission Tomography for Range Verification of Proton Therapy

F. Neri: Study on Proton Beam Incuced Activation of Materials from the SIRMIO Small Animal Irradiaton Platform

Bachelor Thesis (internal):

Hürdler V::  Validation of Catheter Localization Accuracy with a Mobile Cone Beam CT Device for Liver Brachytherapy

Schmidt L.: Estimating the Magnetic Field Generated by a Stopping Proton in an Inhomogeneous Target

Schwaiger S.: Calibration and Commissioning of a Small-Animal Proton Imaging Setup Based on Timepix3 Detectors

Fischer B.: Development of a Measurement for the Spin Relaxation Time of an Optical Magnetometry Setup

Spiering J.: Image Reconstruction of MR-Linac Raw Data for Imaging Latency Evaluation

Sauder M.: Influence of Piezoelectric Ringing on the properties of a Pockels Cell Acting as a Pulse Picker for Optical Probing

Oberle M.: Investigation on Optical Clearing in Hyperspectral Imaging

L. Bormann: Development of an automated setup for Characterisation of a CeBr3-Scintillatorcrystal, for the usage in Compton Cameras

Master Thesis (external):

Zounek A: Assessment of Radiomic Feature Robustness against Reconstruction Settings, Segmentation Settings, and Scanning Devices using a 3D printed Phantom for the clinical PET Analysis of Glioma Patients (LMU Klinik für Nuklearmedizin)

 Bachelor Thesis (external):

Zulassungsarbeit (State exam thesis):